Muir-Torre Syndrome in a Middle-Aged Chinese Patient with Sebaceous Carcinoma of the Eyelid

Muir-Torre syndrome is a rare, autosomal dominant condition characterized by the presence of a skin tumor of sebaceous differentiation and visceral malignancies. We reviewed the case of a 46-year-old Chinese man who had a bleeding mass over the right upper eyelid. He had a history of colon cancer an...

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Bibliographic Details
Published in:Seminars in ophthalmology 2015-11, Vol.30 (5-6), p.420-422
Main Authors: Wong, Ching-Yuen, Tang, Raymond Kai-Tat, Lam, Robert Fung, Io, Ida Yu-Fong, Yuen, Can Yin-Fun, Ho, Judy Wai-Chu, Tse, Raymond Kwok-Kay
Format: Article
Language:English
Subjects:
Adenocarcinoma, Sebaceous - pathology
Adenocarcinoma, Sebaceous - surgery
Asian Continental Ancestry Group - ethnology
China - epidemiology
Colorectal Neoplasms, Hereditary Nonpolyposis - pathology
Eyelid Neoplasms - pathology
Eyelid Neoplasms - surgery
Humans
Male
Middle Aged
Muir-Torre Syndrome - diagnosis
Muir-Torre Syndrome - surgery
Positron-Emission Tomography
Sebaceous Gland Neoplasms - pathology
Sebaceous Gland Neoplasms - surgery
Tomography, X-Ray Computed
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Summary:Muir-Torre syndrome is a rare, autosomal dominant condition characterized by the presence of a skin tumor of sebaceous differentiation and visceral malignancies. We reviewed the case of a 46-year-old Chinese man who had a bleeding mass over the right upper eyelid. He had a history of colon cancer and a family history satisfying the Amsterdam criteria for hereditary non-polyposis colorectal cancer syndrome with germline mutation in the MutS homolog-2 gene. The eyelid lesion was excised completely and submitted for histopathologic examination which showed sebaceous carcinoma. Frozen section and conjunctival map biopsy showed no residual malignancy or local metastasis. Post-operative positron-emission tomography with combined computed tomography did not reveal any residual or visceral malignancy. He had no recurrence in the 32-month follow-up period. We should consider Muir-Torre syndrome in patients with sebaceous carcinoma, especially in the presence of personal and/or family history of visceral malignancies.
ISSN:0882-0538
1744-5205
DOI:10.3109/08820538.2013.833267