Vitamin D and Cardiovascular Disease

Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been con...

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Bibliographic Details
Published in:Annual review of medicine 2016-01, Vol.67 (1), p.261-272
Main Author: Wang, Thomas J
Format: Article
Language:English
Subjects:
Animals
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Cholecalciferol - metabolism
Cholecalciferol - therapeutic use
Clinical trials
Dietary Supplements
Epidemiology
Humans
Hypertension
prevention
Randomized Controlled Trials as Topic
Renin-Angiotensin System
Risk Factors
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - metabolism
Vitamin D - pharmacology
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - epidemiology
Vitamin deficiency
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Summary:Vitamin D is best known for its influence on skeletal health. There is growing recognition, however, that vitamin D has nonskeletal actions, which could have important implications for understanding the consequences of vitamin D deficiency. In epidemiologic studies, vitamin D deficiency has been consistently associated with an increased risk for cardiovascular disease and hypertension. Disruption of vitamin D signaling in animal models promotes hypertension, cardiac hypertrophy, and atherosclerosis. This evidence has led to the initiation of prospective randomized trials of vitamin D supplementation in individuals at risk for cardiovascular disease. The results of these trials should help to guide strategies for screening and management of vitamin D deficiency in the clinic and at the population level.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-051214-025146