Increased Mean Platelet Volume in Familial Hypercholesterolemia

• Published in: Angiology 2016-02, Vol.67 (2), p.146-150
• Main Authors: Icli, Atilla, Aksoy, Fatih, Nar, Gökay, Kaymaz, Haci, Alpay, Mehmet Fatih, Nar, Rukiye, Guclu, Aydın, Arslan, Akif, Dogan, Abdullah
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Blood Platelets; Case-Control Studies; Chi-Square Distribution; Cholesterol - blood; Cross-Sectional Studies; Female; Humans; Hyperlipoproteinemia Type II - blood; Hyperlipoproteinemia Type II - diagnosis; Hyperlipoproteinemia Type II - genetics; Linear Models; Male; Mean Platelet Volume; Middle Aged; Platelet Activation; Platelet Count; Predictive Value of Tests; Turkey
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/0003319715579781

Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism and increases the risk of premature cardiovascular diseases. In patients with FH, platelet function may be activated; however, the extent of this activation and its etiology are unclear. We aimed to evaluate the mean platelet volume (MPV), a marker of platelet activation, in patients with FH. The study group consisted of 164 patients with FH and 160 control patients. Controls were matched for age, gender, hypertension, and smoking. The MPV was significantly higher in patients with FH than in controls (9.2 ± 0.4 vs 7.9 ± 0.6 fL, respectively; P < .001). Platelet count was significantly lower among patients with FH when compared to control patients (259 ± 51 vs 272 ± 56 × 103/L, respectively; P = .03). In linear regression analysis, MPV was independently associated only with total cholesterol (β = .6, 95% confidence interval: 0.004-0.008, P < .001). We have shown that MPV was increased in patients with FH and that it was independently associated with total cholesterol level.