Effects of azelastine nasal spray on nasal and nasopharyngeal microflora

Azelastine nasal spray is a topical antihistaminic drug for the symptomatic treatment of allergic rhinitis. This study aimed to investigate the effects of azelastine on nasal and nasopharyngeal microflora. Swab samples from 25 patients prescribed azelastine nasal spray monotherapy were collected jus...

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Bibliographic Details
Published in:Journal of laryngology and otology 2016-01, Vol.130 (1), p.95-99
Main Authors: Aksoy, F, Senturk, E, Doğan, R, Veyseller, B, Ozturan, O, Gönüllü, N, Yilmaz, F
Format: Article
Language:English
Subjects:
Administration, Intranasal
Adolescent
Adult
Anti-Allergic Agents - pharmacology
Bacteria
Cross-Sectional Studies
Female
Gram-Negative Bacteria - isolation & purification
Gram-Positive Bacteria - isolation & purification
Hay fever
Histamine
Humans
Main Articles
Male
Middle Aged
Nasal Mucosa - microbiology
Nasal Sprays
Nasopharynx - microbiology
Otolaryngology
Pathogens
Patients
Phthalazines - pharmacology
Prospective Studies
Rhinitis
Statistical analysis
Streptococcus infections
Young Adult
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Summary:Azelastine nasal spray is a topical antihistaminic drug for the symptomatic treatment of allergic rhinitis. This study aimed to investigate the effects of azelastine on nasal and nasopharyngeal microflora. Swab samples from 25 patients prescribed azelastine nasal spray monotherapy were collected just before treatment and after 1 month of treatment. After incubation of inoculates, the number of bacteria present in cultures was measured (in colony-forming units per millilitre). Evaluation of the number of microflora revealed increased bacterial reproduction after treatment, but this difference was not statistically significant. The use of azelastine nasal spray decreased the reproduction of three potentially pathogenic bacteria; however, it did not affect the reproduction of other potentially pathogenic bacteria. The use of azelastine nasal spray for one month did not have a statistically significant effect on the numbers of nasal and nasopharyngeal microflora; it is therefore safe from a microbiological viewpoint.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215115002959