Hyperuricemia is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes

Purpose Hyperuricemia/gout and atrial fibrillation (AF) are two pathological conditions that are highly prevalent in type 2 diabetes and share multiple cardiovascular risk factors. However, the relationship between elevated levels of serum uric acid and risk of AF in type 2 diabetes is currently poo...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2016-02, Vol.39 (2), p.159-167
Main Authors: Mantovani, A., Rigolon, R., Pichiri, I., Pernigo, M., Bergamini, C., Zoppini, G., Bonora, E., Targher, G.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Allopurinol - therapeutic use
Atrial Fibrillation - complications
Atrial Fibrillation - epidemiology
Atrial Fibrillation - prevention & control
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic Cardiomyopathies - complications
Diabetic Cardiomyopathies - epidemiology
Diabetic Cardiomyopathies - prevention & control
Electronic Health Records
Endocrinology
Female
Gout - prevention & control
Gout Suppressants - therapeutic use
Hospitalization
Hospitals, University
Humans
Hyperuricemia - complications
Hyperuricemia - drug therapy
Italy - epidemiology
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Prevalence
Retrospective Studies
Risk
Uric Acid - blood
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Summary:Purpose Hyperuricemia/gout and atrial fibrillation (AF) are two pathological conditions that are highly prevalent in type 2 diabetes and share multiple cardiovascular risk factors. However, the relationship between elevated levels of serum uric acid and risk of AF in type 2 diabetes is currently poorly known. Methods We studied a hospital-based sample of 842 (male/female = 463/379) patients with type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. Hyperuricemia was defined as a serum uric acid level >7 mg/dl for men and >6 mg/dl for women or allopurinol use. The diagnosis of AF was confirmed in affected participants on the basis of ECGs and medical history by experienced cardiologists. Results Overall, 243 (28.9 %) patients had hyperuricemia and 91 (10.8 %) patients had persistent or permanent AF. Compared with those with normal serum uric acid levels, patients with hyperuricemia had a remarkably greater prevalence of AF (20.6 vs. 7.1 %; p  
ISSN:1720-8386
1720-8386
DOI:10.1007/s40618-015-0354-z