Correlation between vascular endothelial growth factor and subclinical atherosclerosis in patients with psoriasis

Background Psoriasis is associated with increased risk of atherosclerotic disorders. Vascular endothelial growth factor (VEGF) is an angiogenic factor that was overexpressed in both psoriatic and atherosclerotic lesions. In a prospective controlled study, we investigated the correlation between seru...

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Bibliographic Details
Published in:International journal of dermatology 2016-01, Vol.55 (1), p.52-59
Main Authors: Shahidi-Dadras, Mohammad, Haghighatkhah, Hamid Reza, Abdollahimajd, Fahimeh, Younespour, Shima, Partovi kia, Masoud, Zargari, Omid
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analysis of Variance
Atherosclerosis - blood
Atherosclerosis - physiopathology
Biomarkers - blood
Case-Control Studies
Disease Progression
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Prognosis
Psoriasis - blood
Psoriasis - physiopathology
Reference Values
Severity of Illness Index
Vascular Endothelial Growth Factor A - blood
Young Adult
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Summary:Background Psoriasis is associated with increased risk of atherosclerotic disorders. Vascular endothelial growth factor (VEGF) is an angiogenic factor that was overexpressed in both psoriatic and atherosclerotic lesions. In a prospective controlled study, we investigated the correlation between serum levels of VEGF and subclinical atherosclerosis in patients with moderate to severe psoriasis. Method Sixty patients with moderate to severe psoriasis and 60 age‐ and gender‐matched healthy controls were recruited to the study. Mean intima‐media thickness of the common carotid artery (MIMT‐CCA) and serum VEGF levels of all subjects were measured. Subclinical atherosclerosis was defined as having an MIMT‐CCA ≥0.8 mm. Results Serum VEGF levels in psoriatic patients were significantly higher compared with healthy controls (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.12842