Short Peptides and Telomere Length Regulator Hormone Irisin

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016, Vol.160 (3), p.347-349
Main Authors: Khavinson, V. Kh, Kuznik, B. I., Tarnovskaya, S. I., Lin’kova, N. S.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chromosomes
Epigenesis, Genetic - genetics
Epigenetic inheritance
Fibronectins - genetics
Fibronectins - metabolism
Gene expression
Glycine
Hormones
Humans
Internal Medicine
Laboratory Medicine
Mice
Pathology
Peptides
Peptides - genetics
Peptides - metabolism
Telomere - genetics
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Summary:Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3167-y