Translating plasma and whole blood fatty acid compositional data into the sum of eicosapentaenoic and docosahexaenoic acid in erythrocytes

Abstract Specific blood levels of eicosapentaenoic plus docosahexaenoic acid (EPA+DHA, wt% of total) in erythrocytes or “the omega-3 index” have been recommended for cardio-protection, but fatty acids are often measured in different blood fractions. The ability to estimate the % of EPA+DHA in erythr...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2016-01, Vol.104, p.1-10
Main Authors: Stark, Ken D, Aristizabal Henao, Juan J, Metherel, Adam H, Pilote, Louise
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advanced Basic Science
Docosahexaenoic acid
Docosahexaenoic Acids - blood
Eicosapentaenoic acid
Eicosapentaenoic Acid - blood
Endocrinology & Metabolism
Erythrocyte
Erythrocytes - metabolism
Fatty Acids - blood
Female
Humans
Male
Middle Aged
Plasma
Prospective Studies
Translation
Whole blood
Young Adult
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Summary:Abstract Specific blood levels of eicosapentaenoic plus docosahexaenoic acid (EPA+DHA, wt% of total) in erythrocytes or “the omega-3 index” have been recommended for cardio-protection, but fatty acids are often measured in different blood fractions. The ability to estimate the % of EPA+DHA in erythrocytes from the fatty acid composition of other blood fractions would enable clinical assessments of omega-3 status when erythrocyte fractions are not available and increase the ability to compare blood levels of omega-3 fatty acids across clinical studies. The fatty acid composition of baseline plasma, erythrocytes and whole blood samples from participants ( n =1104) in a prospective, multicenter study examining acute coronary syndrome were determined. The ability to predict the % of EPA+DHA in erythrocytes from other blood fractions were examined using bivariate and multiple linear regression modelling. Concordance analysis was also used to compare the actual erythrocytes EPA+DHA values to values estimated from other blood fractions. EPA+DHA in erythrocytes was significantly ( p
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2015.11.002