Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride

Propranolol administration through buccal route offers some distinct advantages thanks to the easy access to the oral mucosa, fast onset of action, and avoidance of hepatic and intestinal degradation mechanisms. To overcome the effective removal existing in the buccal cavity, mucoadhesive delivery s...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2015-12, Vol.104 (12), p.4365-4372
Main Authors: Abruzzo, Angela, Cerchiara, Teresa, Bigucci, Federica, Gallucci, Maria Caterina, Luppi, Barbara
Format: Article
Language:English
Subjects:
Adhesiveness
Administration, Buccal
Animals
buccal
Chemistry, Pharmaceutical - methods
chitosan
Chitosan - chemistry
Drug Carriers - chemistry
drug delivery systems
Drug Delivery Systems - methods
Gelatin - chemistry
hydrogels
microparticles
Microspheres
Mouth Mucosa - metabolism
mucoadhesive
Propranolol - chemistry
Propranolol - metabolism
spray drying
Swine
tablet
Tablets - chemistry
Tablets - metabolism
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Summary:Propranolol administration through buccal route offers some distinct advantages thanks to the easy access to the oral mucosa, fast onset of action, and avoidance of hepatic and intestinal degradation mechanisms. To overcome the effective removal existing in the buccal cavity, mucoadhesive delivery systems are considered a promising approach as they facilitate a close contact with the buccal mucosa. The aim of this study was to prepare mucoadhesive tablets based on chitosan/gelatin microparticles for buccal delivery of propranolol hydrochloride. Spray-dried microparticles were prepared with different chitosan–gelatin weight ratios and characterized in terms of yield and morphology. Microparticles were subsequently compressed with the drug to obtain loaded buccal tablets. In vitro water uptake, mucoadhesion, release, and permeation tests were performed to investigate tablet ability to hydrate, to adhere to the mucosa, and to deliver drug through buccal mucosa. Microparticles showed a different morphology based on the different chitosan–gelatin weight ratios. Moreover, buccal tablets based on the prepared microparticles showed different technological and functional characteristics in virtue of their composition. In particular, tablets with an excess of chitosan showed the best mucoadhesive properties, allowed the permeation of the greatest drug amount among all formulations, and could be promising for buccal administration of propranolol hydrochloride.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.24688