Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults

We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR...

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Bibliographic Details
Published in:Clinica chimica acta 2016-01, Vol.453, p.197-202
Main Authors: Shih, Kuang-Chung, Janckila, Anthony J., Lee, Wei-Jei, Chou, Yu-Ching, Huang, Chun-Jui, Kwok, Ching-Fai, Ho, Low-Tone, Chao, Tsu-Yi
Format: Article
Language:English
Subjects:
Acid Phosphatase - blood
Adult
Asian Continental Ancestry Group
Bariatric Surgery
Blood Glucose - metabolism
C-Reactive Protein - metabolism
Case-Control Studies
Cytokines - blood
Diabetes mellitus
Female
Humans
Inflammation - blood
Inflammatory cytokine
Insulin Resistance
Isoenzymes - blood
Lipids - blood
Male
Metabolic syndrome
Obesity - blood
Obesity - surgery
Tartrate-Resistant Acid Phosphatase
Tartrate-resistant acid phosphatase 5a
Weight Loss
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Summary:We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively. Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6. Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults. •Effects of bariatric weight loss surgery on serum TRACP 5a in obese adults•Effects of bariatric weight loss surgery on glucose metabolism in obese adults•Effects of bariatric weight loss surgery on inflammatory cytokines in obese adults
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2015.11.004