The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholester...

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Bibliographic Details
Published in:Food & function 2016-01, Vol.7 (1), p.434-444
Main Authors: Herrera Chalé, Francisco, Ruiz Ruiz, Jorge Carlos, Betancur Ancona, David, Acevedo Fernández, Juan José, Segura Campos, Maira Rubi
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - drug effects
Cells, Cultured
Cholesterol - chemistry
Diabetes Mellitus, Experimental
Dose-Response Relationship, Drug
Female
Fibrinolytic Agents - chemistry
Fibrinolytic Agents - pharmacology
Humans
Hypercholesterolemia - drug therapy
Hyperlipidemias - drug therapy
Micelles
Mucuna - chemistry
Platelet Aggregation - drug effects
Protein Hydrolysates - chemistry
Protein Hydrolysates - pharmacology
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Rats
Rats, Wistar
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Summary:Hydrolysates and peptide fractions (PF) obtained from M. pruriens protein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities. Hydrolysates obtained with Pepsin-Pancreatin (PP) and their peptide fractions inhibited cholesterol micellar solubility with a maximum value of 1.83% in PP. Wistar rats were used to evaluate the hypolipidemic effect of hydrolysates and PF. The higher reductions of cholesterol and triglyceride levels were exhibited by PP and both peptide fractions 10 kDa from both hydrolysates showed the maximum antithrombotic activity with values of 33.33% for PF > 10 kDa from AF and 31.72% for PF > 10 kDa from PP. The results suggest that M. pruriens bioactive peptides with the hypolipidemic effect and antithrombotic activity might be utilized as nutraceuticals.
ISSN:2042-6496
2042-650X
DOI:10.1039/c5fo01012h