The impact of lower urinary tract symptoms on health-related quality of life among patients with multiple sclerosis

Aims Lower urinary tract symptoms are commonly experienced among patients with multiple sclerosis (MS), however, their impact on health‐related quality of life (HRQOL) has not been well characterized. Herein the incremental impact of lower urinary tract symptoms on HRQOL among patients with MS has b...

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Published in:Neurourology and urodynamics 2016-01, Vol.35 (1), p.48-54
Main Authors: Khalaf, Kristin M., Coyne, Karin S., Globe, Denise R., Malone, Daniel C., Armstrong, Edward P., Patel, Vaishali, Burks, Jack
Format: Article
Language:English
Subjects:
Adult
Cross-Sectional Studies
epidemiology
Female
Health Status
Health Surveys
Humans
Lower Urinary Tract Symptoms - etiology
Lower Urinary Tract Symptoms - physiopathology
Male
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
outcome assessment
Quality of Life
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container_start_page 48
container_title Neurourology and urodynamics
container_volume 35
creator Khalaf, Kristin M.
Coyne, Karin S.
Globe, Denise R.
Malone, Daniel C.
Armstrong, Edward P.
Patel, Vaishali
Burks, Jack
description Aims Lower urinary tract symptoms are commonly experienced among patients with multiple sclerosis (MS), however, their impact on health‐related quality of life (HRQOL) has not been well characterized. Herein the incremental impact of lower urinary tract symptoms on HRQOL among patients with MS has been evaluated. Methods A cross‐sectional online survey was administered to US residents with a self‐reported MS diagnosis. Data pertaining to demographics, disease history, urinary symptoms, and HRQOL, including the Short Form 36, version 2 (SF‐36v2), were collected. Patients were stratified into four urinary symptom groups: no/minimal urinary symptoms, urinary urgency (UU), urinary urgency incontinence (UUI), and other lower urinary tract symptoms. Multiple linear regression models evaluated the impact of these symptoms. Results Out of the 1,052 respondents, mean age was 47.8 ± 10.6 years; mean time since MS diagnosis was 8.5 ± 7.8 years. UUI and UU subgroups showed the greatest adjusted HRQOL decrement compared with the no/minimal urinary symptoms group, scoring 2.8 (SE ± 0.7, UUI) and 3.5 (SE ± 0.8, UU) points lower on SF‐36v2 Physical Component Summary, respectively, and 3.7 (SE ± 1.0, UUI) and 5.0 (SE ± 1.2, UU) points lower on SF‐36v2 Mental Component Summary (P 
doi_str_mv 10.1002/nau.22670
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Herein the incremental impact of lower urinary tract symptoms on HRQOL among patients with MS has been evaluated. Methods A cross‐sectional online survey was administered to US residents with a self‐reported MS diagnosis. Data pertaining to demographics, disease history, urinary symptoms, and HRQOL, including the Short Form 36, version 2 (SF‐36v2), were collected. Patients were stratified into four urinary symptom groups: no/minimal urinary symptoms, urinary urgency (UU), urinary urgency incontinence (UUI), and other lower urinary tract symptoms. Multiple linear regression models evaluated the impact of these symptoms. Results Out of the 1,052 respondents, mean age was 47.8 ± 10.6 years; mean time since MS diagnosis was 8.5 ± 7.8 years. UUI and UU subgroups showed the greatest adjusted HRQOL decrement compared with the no/minimal urinary symptoms group, scoring 2.8 (SE ± 0.7, UUI) and 3.5 (SE ± 0.8, UU) points lower on SF‐36v2 Physical Component Summary, respectively, and 3.7 (SE ± 1.0, UUI) and 5.0 (SE ± 1.2, UU) points lower on SF‐36v2 Mental Component Summary (P &lt; 0.001 for all), respectively. Conclusions Both UU and UUI symptoms contribute to a decrement in HRQOL among patients with MS. Neurourol. Urodynam. 35:48–54, 2016. ©The Authors. Neurourology and Urodynamics published by Wiley Periodicals, Inc.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.22670</identifier><identifier>PMID: 25327401</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Cross-Sectional Studies ; epidemiology ; Female ; Health Status ; Health Surveys ; Humans ; Lower Urinary Tract Symptoms - etiology ; Lower Urinary Tract Symptoms - physiopathology ; Male ; Middle Aged ; Multiple Sclerosis - complications ; Multiple Sclerosis - physiopathology ; outcome assessment ; Quality of Life</subject><ispartof>Neurourology and urodynamics, 2016-01, Vol.35 (1), p.48-54</ispartof><rights>The Authors. published by Wiley Periodicals, Inc.</rights><rights>The Authors. Neurourology and Urodynamics published by Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4610-e31ae1b58ccd0b3405120e467aac7b9ef0fa0af29432ab34dfbfc972f6cc77243</citedby><cites>FETCH-LOGICAL-c4610-e31ae1b58ccd0b3405120e467aac7b9ef0fa0af29432ab34dfbfc972f6cc77243</cites><orcidid>0000-0002-2960-9931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25327401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalaf, Kristin M.</creatorcontrib><creatorcontrib>Coyne, Karin S.</creatorcontrib><creatorcontrib>Globe, Denise R.</creatorcontrib><creatorcontrib>Malone, Daniel C.</creatorcontrib><creatorcontrib>Armstrong, Edward P.</creatorcontrib><creatorcontrib>Patel, Vaishali</creatorcontrib><creatorcontrib>Burks, Jack</creatorcontrib><title>The impact of lower urinary tract symptoms on health-related quality of life among patients with multiple sclerosis</title><title>Neurourology and urodynamics</title><addtitle>Neurourol. Urodynam</addtitle><description>Aims Lower urinary tract symptoms are commonly experienced among patients with multiple sclerosis (MS), however, their impact on health‐related quality of life (HRQOL) has not been well characterized. Herein the incremental impact of lower urinary tract symptoms on HRQOL among patients with MS has been evaluated. Methods A cross‐sectional online survey was administered to US residents with a self‐reported MS diagnosis. Data pertaining to demographics, disease history, urinary symptoms, and HRQOL, including the Short Form 36, version 2 (SF‐36v2), were collected. Patients were stratified into four urinary symptom groups: no/minimal urinary symptoms, urinary urgency (UU), urinary urgency incontinence (UUI), and other lower urinary tract symptoms. Multiple linear regression models evaluated the impact of these symptoms. Results Out of the 1,052 respondents, mean age was 47.8 ± 10.6 years; mean time since MS diagnosis was 8.5 ± 7.8 years. UUI and UU subgroups showed the greatest adjusted HRQOL decrement compared with the no/minimal urinary symptoms group, scoring 2.8 (SE ± 0.7, UUI) and 3.5 (SE ± 0.8, UU) points lower on SF‐36v2 Physical Component Summary, respectively, and 3.7 (SE ± 1.0, UUI) and 5.0 (SE ± 1.2, UU) points lower on SF‐36v2 Mental Component Summary (P &lt; 0.001 for all), respectively. Conclusions Both UU and UUI symptoms contribute to a decrement in HRQOL among patients with MS. Neurourol. Urodynam. 35:48–54, 2016. ©The Authors. 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Urodynam</addtitle><date>2016-01</date><risdate>2016</risdate><volume>35</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>Aims Lower urinary tract symptoms are commonly experienced among patients with multiple sclerosis (MS), however, their impact on health‐related quality of life (HRQOL) has not been well characterized. Herein the incremental impact of lower urinary tract symptoms on HRQOL among patients with MS has been evaluated. Methods A cross‐sectional online survey was administered to US residents with a self‐reported MS diagnosis. Data pertaining to demographics, disease history, urinary symptoms, and HRQOL, including the Short Form 36, version 2 (SF‐36v2), were collected. Patients were stratified into four urinary symptom groups: no/minimal urinary symptoms, urinary urgency (UU), urinary urgency incontinence (UUI), and other lower urinary tract symptoms. Multiple linear regression models evaluated the impact of these symptoms. Results Out of the 1,052 respondents, mean age was 47.8 ± 10.6 years; mean time since MS diagnosis was 8.5 ± 7.8 years. UUI and UU subgroups showed the greatest adjusted HRQOL decrement compared with the no/minimal urinary symptoms group, scoring 2.8 (SE ± 0.7, UUI) and 3.5 (SE ± 0.8, UU) points lower on SF‐36v2 Physical Component Summary, respectively, and 3.7 (SE ± 1.0, UUI) and 5.0 (SE ± 1.2, UU) points lower on SF‐36v2 Mental Component Summary (P &lt; 0.001 for all), respectively. Conclusions Both UU and UUI symptoms contribute to a decrement in HRQOL among patients with MS. Neurourol. Urodynam. 35:48–54, 2016. ©The Authors. 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subjects Adult
Cross-Sectional Studies
epidemiology
Female
Health Status
Health Surveys
Humans
Lower Urinary Tract Symptoms - etiology
Lower Urinary Tract Symptoms - physiopathology
Male
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
outcome assessment
Quality of Life
title The impact of lower urinary tract symptoms on health-related quality of life among patients with multiple sclerosis
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