Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy

Summary The data regarding radial scar (RS) as a risk factor for breast cancer are conflicting, and it is unclear whether an excision is warranted for patients with RS identified on core needle biopsy (CNB). In this study, we investigated the follow-up excisional results for patients with RS on CNB...

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Bibliographic Details
Published in:Human pathology 2016-02, Vol.48, p.76-80
Main Authors: Li, Zaibo, MD, PhD, Ranade, Aditi, MD, Zhao, Chengquan, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Atypical ductal hyperplasia
Biopsy, Large-Core Needle
Breast cancer
Breast core needle biopsy
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Cohort Studies
Ductal carcinoma in situ
Female
Follow-Up Studies
Humans
Invasive carcinoma
Mammography
Middle Aged
Pathology
Patients
Precancerous Conditions - pathology
Radial scar
Risk Factors
Studies
Young Adult
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Summary:Summary The data regarding radial scar (RS) as a risk factor for breast cancer are conflicting, and it is unclear whether an excision is warranted for patients with RS identified on core needle biopsy (CNB). In this study, we investigated the follow-up excisional results for patients with RS on CNB with no history of or concurrent breast cancer or atypical proliferative lesions. The study cohort was composed of 403 such cases, and follow-up excision (FUE) was performed in 220 (54.6%). There was no significant difference in the radiologic findings in cases with and without FUE. Of the 220 cases with FUE, only 2 (0.9%) were upgraded to malignancy (1 invasive carcinoma and 1 ductal carcinoma in situ), whereas 44 cases (20.0%) were upgraded to atypical ductal hyperplasia and 13 cases (5.9%) to lobular neoplasia. Upgrades were associated with greater age but not with any other variable. This is one of the largest studies to evaluate excisional findings in patients with RS identified on CNB but no history of or concurrent breast cancer or atypical proliferative lesions, and the extremely low malignancy-upgrade rate indicates that conservative follow-up with imaging rather than surgical excisions may be more appropriate for these patients.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2015.06.028