Access to 3‑Acyl-(2H)‑indazoles via Rh(III)-Catalyzed C–H Addition and Cyclization of Azobenzenes with α‑Keto Aldehydes

The rhodium­(III)-catalyzed direct C–H functionalization of azobenzenes with ethyl glyoxalate and aryl glyoxals is described. This protocol provides the facile and efficient formation of various C3-acylated-(2H)-indazoles in moderate to high yields.

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Bibliographic Details
Published in:Organic letters 2016-01, Vol.18 (2), p.232-235
Main Authors: Jeong, Taejoo, Han, Sang Hoon, Han, Sangil, Sharma, Satyasheel, Park, Jihye, Lee, Jong Suk, Kwak, Jong Hwan, Jung, Young Hoon, Kim, In Su
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Azo Compounds - chemistry
Catalysis
Cyclization
Glyoxal - analogs & derivatives
Glyoxal - chemistry
Indazoles - chemical synthesis
Indazoles - chemistry
Ketones - chemistry
Molecular Structure
Rhodium - chemistry
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Description
Summary:The rhodium­(III)-catalyzed direct C–H functionalization of azobenzenes with ethyl glyoxalate and aryl glyoxals is described. This protocol provides the facile and efficient formation of various C3-acylated-(2H)-indazoles in moderate to high yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03368