Vaccines for Antibiotic-Resistant Bacteria: Possibility or Pipe Dream?

The increasing incidence of infections caused by antibiotic-resistant bacteria from multiple species, together with the paucity of new antibiotics in the development pipeline, indicates that vaccines could play a role in combating these infections. The development of vaccines for these infections pr...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2016-02, Vol.37 (2), p.143-152
Main Authors: García-Quintanilla, Meritxell, Pulido, Marina R, Carretero-Ledesma, Marta, McConnell, Michael J
Format: Article
Language:English
Subjects:
Advanced Basic Science
antibiotic resistance
antigen identification
Bacterial Infections - microbiology
Bacterial Infections - prevention & control
Bacterial Vaccines - chemistry
Bacterial Vaccines - genetics
Bacterial Vaccines - immunology
Bacterial Vaccines - pharmacology
clinical trials
Drug Resistance, Microbial
Humans
passive immunization
vaccine
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Summary:The increasing incidence of infections caused by antibiotic-resistant bacteria from multiple species, together with the paucity of new antibiotics in the development pipeline, indicates that vaccines could play a role in combating these infections. The development of vaccines for these infections presents unique challenges related to target population selection, vaccine administration, and antigen identification. Advances in genomic, transcriptomic, and proteomic technologies offer great potential for identifying promising antigens that are highly conserved and expressed during human infections. Although important challenges remain, the potential health and economic benefits associated with the clinical implementation of vaccination strategies for the prevention of antibiotic-resistant infections warrant their continued development.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2015.10.003