Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy

• Published in: The American journal of cardiology 2016, Vol.117 (2), p.282-288
• Main Authors: Shah, Ravi V., MD, Kato, Shingo, MD, PhD, Roujol, Sebastien, PhD, Murthy, Venkatesh, MD, PhD, Bellm, Steven, MD, Kashem, Abyaad, Basha, Tamer, PhD, Jang, Jihye, MS, Eisman, Aaron S., BS, Manning, Warren J., MD, Nezafat, Reza, PhD
• Format: Article
• Language: English
• Subjects: Cardiomyopathies - diagnosis; Cardiomyopathies - physiopathology; Cardiovascular; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging, Cine - methods; Male; Middle Aged; Myocardium - pathology; Predictive Value of Tests; Prospective Studies; Stroke Volume - physiology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2015.10.046

Diffuse myocardial fibrosis is involved in the pathology of nonischemic cardiomyopathy (NIC). Recently, the application of native (noncontrast) myocardial T1 measurement has been proposed as a method for characterizing diffuse interstitial fibrosis. To determine the association of native T1 with myocardial structure and function, we prospectively studied 39 patients with NIC (defined as left ventricular ejection fraction (LVEF) ≤50% without cardiac magnetic resonance (CMR) evidence of previous infarction) and 27 subjects with normal LVEF without known overt cardiovascular disease. T1, T2, and extracellular volume fraction (ECV) were determined over 16 segments across the base, mid, and apical left ventricular (LV). NIC participants (57 ± 15 years) were predominantly men (74%), with a mean LVEF 34 ± 10%. Subjects with NIC had a greater native T1 (1,131 ± 51 vs 1,069 ± 29 ms; p