Serendipitous detection of Hemoglobin G-Ferrara variant with Sysmex DIFF channel

A low DIFF channel fluorescence (Sysmex XE technology) may reveal the presence of a variant hemoglobin. In this patient Hemoglobin G Ferrara was demonstrated. [Display omitted] •Greater area laboratories favor the occurrence of uncommon findings.•Low fluorescence DIFF scattergrams signal may hide th...

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Bibliographic Details
Published in:Clinical biochemistry 2016-01, Vol.49 (1-2), p.192-193
Main Authors: Rosetti, Marco, Poletti, Giovanni, Ivaldi, Giovanni, Rondoni, Michela, Baldrati, Luca, Dorizzi, Romolo M.
Format: Article
Language:English
Subjects:
Abnormal hemoglobin
Chromatography, High Pressure Liquid
DNA - genetics
Fluorescent dyes
Hematology
Hemoglobin G-Ferrara
Hemoglobins, Abnormal - analysis
Hemoglobins, Abnormal - genetics
High performance liquid chromatography
Humans
Polymerase Chain Reaction
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Summary:A low DIFF channel fluorescence (Sysmex XE technology) may reveal the presence of a variant hemoglobin. In this patient Hemoglobin G Ferrara was demonstrated. [Display omitted] •Greater area laboratories favor the occurrence of uncommon findings.•Low fluorescence DIFF scattergrams signal may hide the presence of Hb G-Ferrara.•Alterations of automated hematology tests can reveal an unsuspected diagnosis.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2015.09.009