Self-assembling tryptophan-based designer peptides as intracellular delivery vehicles

[Display omitted] A series of tryptophan-based peptides W1a, b–W4a, b, with diverse architectures were designed and synthesized. These tryptophan containing peptides can self-assemble to spherical particle. This self-assembled system was demonstrated to encapsulate rhodamine B and penetrate the cell...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2016-01, Vol.26 (2), p.672-676
Main Authors: Bhardwaj, Ishanki, Jha, Divya, Admane, Prasad, Panda, Amulya K., Haridas, V.
Format: Article
Language:English
Subjects:
Animals
Cell Line
Dendrimers - chemistry
Drug Carriers - chemistry
Encapsulation
Mice
Peptide
Peptides - chemistry
Rhodamines - administration & dosage
Self-assembly
Spherical assembly
Tryptophan
Tryptophan - chemistry
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Summary:[Display omitted] A series of tryptophan-based peptides W1a, b–W4a, b, with diverse architectures were designed and synthesized. These tryptophan containing peptides can self-assemble to spherical particle. This self-assembled system was demonstrated to encapsulate rhodamine B and penetrate the cell membrane.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.11.041