Epicardial Adipose Tissue Accumulation Is Associated With Renal Dysfunction and Coronary Plaque Morphology on Multidetector Computed Tomography

Background:Chronic kidney disease (CKD) is strongly associated with coronary artery disease (CAD), although the underlying pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) has recently been recognized as an important source of various pro-inflammatory cytokines causing c...

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Bibliographic Details
Published in:Circulation Journal 2015/12/25, Vol.80(1), pp.196-201
Main Authors: Nakanishi, Koki, Fukuda, Shota, Tanaka, Atsushi, Otsuka, Kenichiro, Taguchi, Haruyuki, Yoshikawa, Junichi, Shimada, Kenei
Format: Article
Language:English
Subjects:
Adipose Tissue - diagnostic imaging
Aged
Chronic kidney disease
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Epicardial adipose tissue
Female
Humans
Male
Middle Aged
Multidetector Computed Tomography
Pericardium - diagnostic imaging
Plaque, Atherosclerotic - diagnostic imaging
Renal Insufficiency, Chronic - diagnostic imaging
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Summary:Background:Chronic kidney disease (CKD) is strongly associated with coronary artery disease (CAD), although the underlying pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) has recently been recognized as an important source of various pro-inflammatory cytokines causing coronary atherosclerosis. This study investigated the relationship between CKD and EAT volume in association with high-risk plaque.Methods and Results:The study included 275 patients with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2who underwent multidetector computed tomography (MDCT) for the evaluation of CAD. Patients were classified, according to eGFR, into a CKD group (30≤eGFR
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-15-0477