Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma

Purpose To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan–Meier analysis with log-rank test was used...

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Bibliographic Details
Published in:World journal of urology 2016-01, Vol.34 (1), p.97-103
Main Authors: Gakis, Georgios, Morgan, Todd M., Efstathiou, Jason A., Keegan, Kirk A., Mischinger, Johannes, Todenhoefer, Tilman, Schubert, Tina, Zaid, Harras B., Hrbacek, Jan, Ali-El-Dein, Bedeir, Clayman, Rebecca H., Galland, Sigolene, Olugbade, Kola, Rink, Michael, Fritsche, Hans-Martin, Burger, Maximilian, Chang, Sam S., Babjuk, Marko, Thalmann, George N., Stenzl, Arnulf, Daneshmand, Siamak
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Age Factors
Aged
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - therapy
Cohort Studies
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Nephrology
Oncology
Original Article
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Survival Rate
Urethral Neoplasms - mortality
Urethral Neoplasms - pathology
Urethral Neoplasms - therapy
Urology
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Summary:Purpose To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). Methods A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan–Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. Results Median age at definitive treatment was 66 years (IQR 58–76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-015-1583-7