5th International ACC Symposium: Old Syndromes with New Biomarkers and New Therapies with Old Medications

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with variable but often aggressive clinical course. Hormonal overproduction can be seen in about half of all ACC cases. When present, the hormonal excess leads to a wide range of metabolic, musculoskeletal, cardiovascular, and infectious...

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Bibliographic Details
Published in:Hormones & cancer 2016-02, Vol.7 (1), p.17-23
Main Authors: Rao, Sarika N., Habra, Mouhammed Amir
Format: Article
Language:English
Subjects:
Adrenal Cortex Neoplasms - drug therapy
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - pathology
Adrenocortical Carcinoma - drug therapy
Adrenocortical Carcinoma - metabolism
Adrenocortical Carcinoma - pathology
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - metabolism
Cell Biology
Congresses as Topic
Endocrinology
Hormones - metabolism
Humans
Internal Medicine
Medicine
Medicine & Public Health
Microbiology
Oncology
Review
Systems Biology
Treatment Outcome
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Summary:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with variable but often aggressive clinical course. Hormonal overproduction can be seen in about half of all ACC cases. When present, the hormonal excess leads to a wide range of metabolic, musculoskeletal, cardiovascular, and infectious complications and adds multiple layers of complexity to the management of ACC. To improve the outcome of patients with hormonally functioning ACC, an effective approach should include parallel efforts to achieve oncologic and hormonal control. An experienced multidisciplinary team is crucial to deliver and coordinate care to manage the specific aspects of this condition. In this review, we summarized the clinical features and management of hormonally functioning ACCs to assist practicing physicians in addressing the complex medical issues that can be seen in the context of this clinical entity.
ISSN:1868-8497
1868-8500
DOI:10.1007/s12672-015-0247-9