Liver transplantation for advanced hepatocellular carcinoma in patients with Child-Pugh A and B

• Published in: Surgery today (Tokyo, Japan) Japan), 2016-02, Vol.46 (2), p.248-254
• Main Authors: Hammad, Ahmed, Kaido, Toshimi, Ogawa, Kohei, Fujimoto, Yasuhiro, Uemura, Tadahiro, Mori, Akira, Hatano, Etsuro, Okajima, Hideaki, Uemoto, Shinji
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - classification; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Female; Humans; Liver Neoplasms - classification; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Liver Transplantation - mortality; Living Donors; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local; Original Article; Surgery; Surgical Oncology; Survival Rate; Treatment Outcome; Young Adult
• ISSN: 0941-1291; 1436-2813
• DOI: 10.1007/s00595-015-1142-2

Purpose To investigate the outcomes of living donor liver transplantation for advanced hepatocellular carcinoma in Child-Pugh A/B patients and the usefulness of our expanded selection criteria, the Kyoto criteria. Methods A total of 82 recipients with a Child-Pugh class A ( n  = 27) or B ( n  = 55) status having either multiple hepatic nodules or solitary tumors ≥5 cm in size treated between February 1999 and August 2012 were enrolled in this study. Results The overall recurrence rate was significantly less for the Child-Pugh B patients than for the Child-Pugh A patients ( P  = 0.042), while the survival rates did not differ. In the Child-Pugh A and B patients, the survival rate was significantly greater, while the recurrence rate was lower among the patients meeting the Kyoto criteria than those exceeding these criteria ( P  = 0.006, P  = 0.001, P  = 0.032 and P