Effect of a 2-year home-based endurance training intervention on physiological function and PSA doubling time in prostate cancer patients

Aim Physical activity after prostate cancer diagnosis has been shown to reduce the risk of disease progression. Here, we aimed to evaluate the effect of a 2-year home-based endurance training intervention on body composition, biomarkers levels, and prostate-specific antigen (PSA) doubling time as a...

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Bibliographic Details
Published in:Cancer causes & control 2016-02, Vol.27 (2), p.165-174
Main Authors: Hvid, Thine, Lindegaard, Birgitte, Winding, Kamilla, Iversen, Peter, Brasso, Klaus, Solomon, Thomas P. J., Pedersen, Bente K., Hojman, Pernille
Format: Article
Language:English
Subjects:
Adiponectin - blood
Aged
Biomarkers
Biomedical and Life Sciences
Biomedicine
Body Composition
Cancer Research
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Disease
Disease Progression
Epidemiology
Exercise
Exercise Test
Exercise Therapy
Glucose Tolerance Test
Hematology
Humans
Insulin Resistance
Insulin-Like Growth Factor Binding Protein 1 - blood
Insulin-Like Growth Factor I - metabolism
Interleukin-6 - blood
Leptin - blood
Male
Metabolism
Middle Aged
Motor Activity
Neoplasm Recurrence, Local - blood
Oncology
ORIGINAL PAPER
Oxygen Consumption
Physical Endurance
Physical fitness
Physiology
Prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - blood
Prostatic Neoplasms - rehabilitation
Prostatic Neoplasms - surgery
Public Health
Risk
Treatment Outcome
Triglycerides - blood
Tumor Necrosis Factor-alpha - blood
Urology
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Summary:Aim Physical activity after prostate cancer diagnosis has been shown to reduce the risk of disease progression. Here, we aimed to evaluate the effect of a 2-year home-based endurance training intervention on body composition, biomarkers levels, and prostate-specific antigen (PSA) doubling time as a surrogate end-point for progressing disease. Methods Out-clinic patients with either biochemical recurrence following radical prostatectomy or patients managed on active surveillance were randomized to either 24 months (3 times/week) of home-based endurance training or usual care. Aerobic fitness, body composition, insulin sensitivity, and biomarkers were measured at 0, 6, and 24 months of intervention. PSA doubling time (PSADT) was calculated based on monthly PSA measurements. Results Twenty-five patients were enrolled, and 19 patients completed the study. PSADT increased in the training group from 28 to 76 months ( p  
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-015-0694-1