Association between Interleukin-10 -1082G/A Gene Polymorphism and Risk of Stroke in the North Indian Population: A Case–Control Study

Background Anti-inflammatory interleukin-10 (IL-10) cytokine and its genetic variations may play an important role in the pathogenesis of various human diseases including stroke. Objective The aim of this present case–control study was to determine the association between IL-10 -1082G/A (rs1800896)...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2016-02, Vol.25 (2), p.461-468
Main Authors: Kumar, Pradeep, PhD, Kumar, Amit, PhD, Sagar, Ram, MSc, Misra, Shubham, M.Tech, Faruq, Mohammad, PhD, Suroliya, Varun, MSc, Vivekanandhan, Subiah, PhD, Srivastava, Achal Kumar, DM, Prasad, Kameshwar, DM
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
anti-inflammatory cytokine
Cardiovascular
Case-Control Studies
cerebrovascular disease
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
India
interleukin-10
Interleukin-10 - genetics
intracerebral hemorrhage
Ischemic stroke
Male
Middle Aged
Neurology
Polymorphism, Single Nucleotide
promoter
single-nucleotide polymorphism
Stroke - genetics
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Summary:Background Anti-inflammatory interleukin-10 (IL-10) cytokine and its genetic variations may play an important role in the pathogenesis of various human diseases including stroke. Objective The aim of this present case–control study was to determine the association between IL-10 -1082G/A (rs1800896) gene polymorphism and risk of stroke in the North Indian population. Methods Genotyping was carried out by using SNaPshot method (Applied Biosystems, Foster City, California, United States) for 250 ischemic stroke (IS) patients, 250 age- and sex-matched IS free controls, 100 intracerebral hemorrhage (ICH) patients, and 100 age- and sex-matched ICH free controls. IS was classified using the Trial of Org 10172 in Acute Stroke Treatment classification. Conditional logistic regression analysis with adjustment for multiple demographic and risk factor variables was used to calculate the strength of association between IL-10 (-1082G/A) polymorphism and risk of stroke. Results Conditional logistic regression analysis showed an independent association between IL-10 -1082G/A and risk of IS under a dominant model (odds ratio [OR] = 2.39, 95% confidence interval [CI] = 1.34-4.27, P  = .003) and an allelic model (OR = 2.49, 95% CI 1.71-3.63, P  
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2015.10.020