Spot Sign in Acute Intracerebral Hemorrhage in Dynamic T1-Weighted Magnetic Resonance Imaging

BACKGROUND AND PURPOSE—In computed tomographic imaging of acute intracerebral hemorrhage spot sign on computed tomographic angiography has been established as a marker for hematoma expansion and poor clinical outcome. Although, magnetic resonance imaging (MRI) can accurately visualize acute intracer...

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Bibliographic Details
Published in:Stroke (1970) 2016-02, Vol.47 (2), p.417-423
Main Authors: Schindlbeck, Katharina A, Santaella, Anna, Galinovic, Ivana, Krause, Thomas, Rocco, Andrea, Nolte, Christian H, Villringer, Kersten, Fiebach, Jochen B
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain - diagnostic imaging
Brain - pathology
Cerebral Angiography
Cerebral Hemorrhage - complications
Cerebral Hemorrhage - diagnosis
Cohort Studies
Disease Progression
Extravasation of Diagnostic and Therapeutic Materials - diagnosis
Female
Hematoma - diagnosis
Hematoma - etiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Middle Aged
Prognosis
Prospective Studies
Stroke - diagnosis
Stroke - etiology
Time Factors
Tomography, X-Ray Computed
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Summary:BACKGROUND AND PURPOSE—In computed tomographic imaging of acute intracerebral hemorrhage spot sign on computed tomographic angiography has been established as a marker for hematoma expansion and poor clinical outcome. Although, magnetic resonance imaging (MRI) can accurately visualize acute intracerebral hemorrhage, a corresponding MRI marker is lacking to date. METHODS—We prospectively examined 50 consecutive patients with acute intracerebral hemorrhage within 24 hours of symptom onset. The MRI protocol consisted of a standard stroke protocol and dynamic contrast-enhanced T1-weighted imaging with a time resolution of 7.07 s/batch. Stroke scores were assessed at admission and at time of discharge. Volume measurements of hematoma size and spot sign were performed with MRIcron. RESULTS—Contrast extravasation within sites of the hemorrhage (MRI spot sign) was seen in 46% of the patients. Patients with an MRI spot sign had a significantly shorter time to imaging than those without (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.115.011570