Significance of Coronary Artery Disease and Left Ventricular Afterload in Unoperated Asymptomatic Aortic Stenosis

Background:Because the covariates of cardiovascular events in unoperated patients with asymptomatic aortic stenosis (AS) have not been adequately evaluated, we aimed to identify them.Methods and Results:A total of 230 patients with asymptomatic severe AS were retrospectively enrolled. The patients w...

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Bibliographic Details
Published in:Circulation Journal 2016/01/25, Vol.80(2), pp.519-525
Main Authors: Shibayama, Kentaro, Daimon, Masao, Watanabe, Hiroyuki, Kawata, Takayuki, Miyazaki, Sakiko, Morimoto-Ichikawa, Ryoko, Maruyama, Masaki, Chiang, Shuo-Ju, Miyauchi, Katsumi, Daida, Hiroyuki
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aortic stenosis
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - mortality
Coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - mortality
Echocardiography
Female
Heart Ventricles
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors
Valve disease surgery
Valvular heart disease
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Summary:Background:Because the covariates of cardiovascular events in unoperated patients with asymptomatic aortic stenosis (AS) have not been adequately evaluated, we aimed to identify them.Methods and Results:A total of 230 patients with asymptomatic severe AS were retrospectively enrolled. The patients were divided into 2 groups based on aortic valve replacement (AVR) after enrollment: a non-AVR group (n=112), and an AVR group (n=118). The primary clinical endpoint was cardiovascular events, which were defined as cardiovascular death or hospitalization. Coronary artery disease [hazard ratio (HR): 3.62, 95% confidence interval (CI): 1.585–8.245, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-15-0876