Centrosome amplification and clonal evolution in multiple myeloma: Short review

•Existence of MM subclones with centrosome amplification.•Evolutionary behavior within intra-clonal heterogeneity.•Potential impact on the disease progression and MM treatment. Multiple myeloma (MM) is composed of an array of multiple clones, each potentially associated with different clinical behav...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2016-02, Vol.98, p.116-121
Main Authors: Kryukova, Elena, Kryukov, Fedor, Hajek, Roman
Format: Article
Language:English
Subjects:
Apoptosis - physiology
Carcinogenesis - pathology
Cell Proliferation
Centrosome - pathology
Centrosome amplification
Clonal diversification
Clonal Evolution - physiology
Clone Cells
Disease Progression
Hematology, Oncology and Palliative Medicine
Humans
Multiple myeloma
Multiple Myeloma - genetics
Multiple Myeloma - pathology
Proliferation
Stress, Physiological - physiology
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Summary:•Existence of MM subclones with centrosome amplification.•Evolutionary behavior within intra-clonal heterogeneity.•Potential impact on the disease progression and MM treatment. Multiple myeloma (MM) is composed of an array of multiple clones, each potentially associated with different clinical behavior. Previous studies focused on clinical implication of centrosome amplification (CA) in MM show contradictory results. It seems that the role of CA as well as CA formation in MM differ from other malignancies. This has brought about a question about the role of CA positive clone which is—is it going to be a more aggressive clone evolutionally arising under pressure of negative conditions or can CA serve as a marker of cell abnormality and lead to cell death and further elimination of this damaged subpopulation? This current review is devoted to the discussion of the existence of MM subclones with centrosome amplification (CA), its evolutionary behaviour within intraclonal heterogeneity as well as its potential impact on the disease progression and MM treatment.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.10.019