Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests

Background Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equiv...

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Bibliographic Details
Published in:Journal of diabetes 2015-11, Vol.7 (6), p.820-829
Main Authors: Deng, Yuying, Zhang, Yifei, Zheng, Sheng, Hong, Jie, Wang, Chunling, Liu, Ting, Sun, Zhehao, Gu, Weiqiong, Gu, Yanyun, Shi, Juan, Yao, Shuangshuang, Wang, Weiqing, Ning, Guang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Blood Glucose - metabolism
C-Peptide - blood
carbohydrates
China
Cross-Over Studies
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Dietary Carbohydrates - administration & dosage
Dietary Carbohydrates - blood
Female
Glucagon - blood
Glucagon-Like Peptide 1 - blood
Glucose Tolerance Test - methods
Humans
incretin effect
Incretins - blood
Insulin - blood
Male
Middle Aged
Postprandial Period
postprandial responses
Predictive Value of Tests
Time Factors
Young Adult
关键词：碳水化合物，肠促胰素效应，餐后效应
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Summary:Background Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equivalently) on postprandial glucose, insulin and incretin responses in different glucose tolerance groups. Methods This study was an open‐label, randomized, two‐way crossover clinical trial. 240 participants were assigned to take two carbohydrates in a randomized order separated by a washout period of 5–7 days. The plasma glucose, insulin, c‐peptide, glucagon and active glucagon‐like peptide‐1 (AGLP‐1) were measured. The incremental area under curve above baseline from 0 to 120 min of insulin (iAUC0–120 min‐INS) and AGLP‐1(iAUC0–120 min‐AGLP‐1) was calculated. Results Compared with standard noodles, the plasma glucose and insulin after consumption of oral glucose were higher at 30 min (both P 
ISSN:1753-0393
1753-0407
DOI:10.1111/1753-0407.12245