Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE

• Published in: Human reproduction (Oxford) 2016-02, Vol.31 (2), p.233-248
• Main Authors: Kupka, M.S., D'Hooghe, T., Ferraretti, A.P., de Mouzon, J., Erb, K., Castilla, J.A., Calhaz-Jorge, C., De Geyter, Ch, Goossens, V.
• Format: Article
• Language: English
• Subjects: Adult; Embryo Transfer - statistics & numerical data; Europe; Female; Fertilization in Vitro - methods; Fertilization in Vitro - statistics & numerical data; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Pregnancy, Multiple - statistics & numerical data; Preimplantation Diagnosis - statistics & numerical data; Registries; Reproductive Techniques, Assisted - statistics & numerical data; Reproductive Techniques, Assisted - trends; Sperm Injections, Intracytoplasmic - statistics & numerical data
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/dev319

Abstract STUDY QUESTION The 15th European IVF-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2011: are there any changes in the trends compared with previous years? SUMMARY ANSWER Despite some fluctuations in the number of countries reporting data, while the overall number of ART cycles has continued to increase year by year, the pregnancy rates in 2011 decreased slightly to those reported in 2010, and the number of transfers with multiple embryos (3+) and the multiple delivery rates declined. WHAT IS KNOWN ALREADY Since 1997, ART data in Europe have been collected and reported in 14 manuscripts, published in Human Reproduction. STUDY DESIGN, SIZE, DURATION Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE); cycles started between 1 January and 31 December 2011 are collected on a yearly basis. The data are collected by National Registers, when existing, or on a voluntary basis by personal information. PARTICIPANTS/MATERIALS SETTING, METHODS From 33 countries (+2 compared with 2010), 1064 clinics reported 609 973 treatment cycles including: IVF 138 592, ICSI 298 918, frozen embryo replacement (FER) 129 693, egg donation (ED) 30 198, in vitro maturation 511, preimplantation genetic diagnosis/screening 6824 and frozen oocyte replacements 5237. European data on intrauterine insemination (IUI) using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 861 IUI laboratories in 24 countries. A total of 174 390 IUI-H and 41 151 IUI-D cycles were included. MAIN RESULTS AND THE ROLE OF CHANCE In 17 countries where all clinics reported to the ART register, a total of 361 972 ART cycles were performed in a population of 285 million inhabitants, corresponding to 1269 cycles per million inhabitants. For all IVF cycles, the clinical pregnancy rates per aspiration and per transfer were stable with 29.1 and 33.2%, respectively, and for ICSI, the corresponding rates also were stable with 27.9 and 31.8%, respectively. In FER cycles, the pregnancy rate per thawing increased to 21.3% if compared with previous years. In ED cycles, the pregnancy rate per fresh transfer decreased to 45.8% (47.4% in 2010) and increased to 33.6% (33.3% in 2010) per thawed transfer. The delivery rate after IUI-H decreased to 8.3 (8.9 in 2010), and to 12.2% (13.8% in 2010) after IUI-D. In IVF and ICSI c