Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study

Summary Objective Cartilage regenerative procedures using the cell-based tissue engineering approach involving mesenchymal stem cells (MSCs) have been receiving increased interest because of their potential for altering the progression of osteoarthritis (OA) by repairing cartilage lesions. The aim o...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2016-02, Vol.24 (2), p.237-245
Main Authors: Kim, Y.S, Choi, Y.J, Lee, S.W, Kwon, O.R, Suh, D.S, Heo, D.B, Koh, Y.G
Format: Article
Language:English
Subjects:
Aged
Arthroscopy
Cartilage, Articular - pathology
Cohort Studies
Female
Fibrin glue
Fibrin Tissue Adhesive - therapeutic use
Humans
Implantation
Knee
Lysholm Knee Score
Magnetic Resonance Imaging
Male
Mesenchymal stem cell
Mesenchymal Stem Cell Transplantation - methods
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - pathology
Osteoarthritis, Knee - physiopathology
Osteoarthritis, Knee - therapy
Patient Satisfaction
Prospective Studies
Rheumatology
Severity of Illness Index
Tissue Adhesives - therapeutic use
Treatment Outcome
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Summary:Summary Objective Cartilage regenerative procedures using the cell-based tissue engineering approach involving mesenchymal stem cells (MSCs) have been receiving increased interest because of their potential for altering the progression of osteoarthritis (OA) by repairing cartilage lesions. The aim of this study was to investigate the clinical and magnetic resonance imaging (MRI) outcomes of MSC implantation in OA knees and to determine the association between clinical and MRI outcomes. Design Twenty patients (24 knees) who underwent arthroscopic MSC implantation for cartilage lesions in their OA knees were evaluated at 2 years after surgery. Clinical outcomes were evaluated according to the International Knee Documentation Committee (IKDC) score and the Tegner activity scale, and cartilage repair was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Results The clinical outcomes significantly improved ( P  
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2015.08.009