The importance of age and menopausal status in endometrial complex hyperplasia with atypia

The effects of menopausal status and age on the intra-operative and post-operative pathology results of patients operated on with a pre-operative diagnosis of complex hyperplasia with atypia (CHA) were assessed. A hundred and eleven patients diagnosed in our centre between January 1993 and March 201...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2016-01, Vol.36 (1), p.102-105
Main Authors: Ureyen, I., Karalok, A., Tasci, T., Turkmen, O., Koc, S., Ozgul, A., Tulunay, G., Turan, T.
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Cancer
endometrial cancer
endometrial complex hyperplasia with atypia
Endometrial Hyperplasia - pathology
Endometrial Hyperplasia - surgery
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - pathology
Female
frozen section
Frozen Sections
Humans
Medical diagnosis
menopausal status
Menopause
Middle Aged
Paraffin Embedding
Postmenopause
Premenopause
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Summary:The effects of menopausal status and age on the intra-operative and post-operative pathology results of patients operated on with a pre-operative diagnosis of complex hyperplasia with atypia (CHA) were assessed. A hundred and eleven patients diagnosed in our centre between January 1993 and March 2013 were included. Cancer was detected in the paraffin blocks (PBs) of 52 (46.8%) patients. Among these, 50 patients had stage-IA disease. In 31.1% of the pre-menopausal patients and 66% of the post-menopausal patients, PB revealed cancer (p < 0.0001). The results of frozen section (FS) and PB were concordant in 51% and 70% in the pre-menopausal and post-menopausal patients, respectively (p = 0.041). In the patients operated on with a pre-operative diagnosis of CHA, the probability of detecting cancer in PB increases with increasing age and menopause. The reliability of FS is limited in younger and pre-menopausal patients.
ISSN:0144-3615
1364-6893
DOI:10.3109/01443615.2015.1036407