Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience

Objective Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. Methods All consecutive patients with acute pancreatitis (AP...

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Bibliographic Details
Published in:Journal of digestive diseases 2015-12, Vol.16 (12), p.734-740
Main Authors: Toqué, Laurence, Hamy, Antoine, Hamel, Jean-Francois, Cesbron, Elodie, Hulo, Pauline, Robert, Solen, Aube, Christophe, Lermite, Emilie, Venara, Aurélien
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism - complications
Female
France - epidemiology
Humans
Hyperglycemia
Hyperglycemia - complications
Incidence
L-Lactate Dehydrogenase - blood
Leukocyte Count
Male
Mesenteric Veins
Middle Aged
Multivariate Analysis
Pancreas
pancreatitis
Pancreatitis - blood
Pancreatitis - complications
Portal Vein
Prothrombin Time
Retrospective Studies
risk factor
Risk Factors
Sex Factors
Smoking - adverse effects
splanchnic vein
Splenic Vein
Thrombosis
Venous Thrombosis - epidemiology
Venous Thrombosis - etiology
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Summary:Objective Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. Methods All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria. Results A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) 75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 109/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH 
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12298