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Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience
Objective Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. Methods All consecutive patients with acute pancreatitis (AP...
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| Published in: | Journal of digestive diseases 2015-12, Vol.16 (12), p.734-740 |
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| container_end_page | 740 |
| container_issue | 12 |
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| container_title | Journal of digestive diseases |
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| creator | Toqué, Laurence Hamy, Antoine Hamel, Jean-Francois Cesbron, Elodie Hulo, Pauline Robert, Solen Aube, Christophe Lermite, Emilie Venara, Aurélien |
| description | Objective
Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors.
Methods
All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria.
Results
A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) 75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 109/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH |
| doi_str_mv | 10.1111/1751-2980.12298 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1761463515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3934603151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4758-4d74742bc20ebfb41e8858a0b610c5035c3b3a87f43f4d9a69b111ad5f1232833</originalsourceid><addsrcrecordid>eNqFkc1P3DAQxa2qqMC2596QJS69BOw4_tje0AIL0gqo-KjUi-U4EzDNJqntLOx_j5eFPXCpL-Oxfu9p_Aah75Qc0HQOqeQ0y8cqtXkqn9DO5uXz5i7zbbQbwiMhXEglvqDtXHDKKGU7yF15qJyNbgG4NjZ2PuCuxqFvTGsfWmfxAlyL44Pv5mUXXMCpM3aIgPtEeDDRRRd-4iMssiUYj4Nr7xvILLQRPIbnHryD1sJXtFWbJsC3tzpCt6cnN5OzbHY5PZ8czTJbSK6yopKFLPLS5gTKuiwoKMWVIaWgxHLCuGUlM0rWBauLamzEuExBmIrXNGe5YmyEfqx9e9_9GyBEPXfBQpM-BN0QNJWCFoJxyhO6_wF97AbfpulWFBHJmKtEHa4p67sQPNS6925u_FJToldb0Kuc9Spz_bqFpNh78x3KOVQb_j32BPA18OQaWP7PT0-Oj9-Ns7XOhQjPG53xf7WQTHL9-2Kq_zB5J35dM33BXgBjaJ-u</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1760611158</pqid></control><display><type>article</type><title>Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Toqué, Laurence ; Hamy, Antoine ; Hamel, Jean-Francois ; Cesbron, Elodie ; Hulo, Pauline ; Robert, Solen ; Aube, Christophe ; Lermite, Emilie ; Venara, Aurélien</creator><creatorcontrib>Toqué, Laurence ; Hamy, Antoine ; Hamel, Jean-Francois ; Cesbron, Elodie ; Hulo, Pauline ; Robert, Solen ; Aube, Christophe ; Lermite, Emilie ; Venara, Aurélien</creatorcontrib><description>Objective
Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors.
Methods
All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria.
Results
A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively).
In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 109/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT.
Conclusions
Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.</description><identifier>ISSN: 1751-2972</identifier><identifier>EISSN: 1751-2980</identifier><identifier>DOI: 10.1111/1751-2980.12298</identifier><identifier>PMID: 26513113</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Alcoholism - complications ; Female ; France - epidemiology ; Humans ; Hyperglycemia ; Hyperglycemia - complications ; Incidence ; L-Lactate Dehydrogenase - blood ; Leukocyte Count ; Male ; Mesenteric Veins ; Middle Aged ; Multivariate Analysis ; Pancreas ; pancreatitis ; Pancreatitis - blood ; Pancreatitis - complications ; Portal Vein ; Prothrombin Time ; Retrospective Studies ; risk factor ; Risk Factors ; Sex Factors ; Smoking - adverse effects ; splanchnic vein ; Splenic Vein ; Thrombosis ; Venous Thrombosis - epidemiology ; Venous Thrombosis - etiology</subject><ispartof>Journal of digestive diseases, 2015-12, Vol.16 (12), p.734-740</ispartof><rights>2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4758-4d74742bc20ebfb41e8858a0b610c5035c3b3a87f43f4d9a69b111ad5f1232833</citedby><cites>FETCH-LOGICAL-c4758-4d74742bc20ebfb41e8858a0b610c5035c3b3a87f43f4d9a69b111ad5f1232833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26513113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toqué, Laurence</creatorcontrib><creatorcontrib>Hamy, Antoine</creatorcontrib><creatorcontrib>Hamel, Jean-Francois</creatorcontrib><creatorcontrib>Cesbron, Elodie</creatorcontrib><creatorcontrib>Hulo, Pauline</creatorcontrib><creatorcontrib>Robert, Solen</creatorcontrib><creatorcontrib>Aube, Christophe</creatorcontrib><creatorcontrib>Lermite, Emilie</creatorcontrib><creatorcontrib>Venara, Aurélien</creatorcontrib><title>Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience</title><title>Journal of digestive diseases</title><addtitle>Journal of Digestive Diseases</addtitle><description>Objective
Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors.
Methods
All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria.
Results
A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively).
In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 109/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT.
Conclusions
Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcoholism - complications</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - complications</subject><subject>Incidence</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Mesenteric Veins</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pancreas</subject><subject>pancreatitis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - complications</subject><subject>Portal Vein</subject><subject>Prothrombin Time</subject><subject>Retrospective Studies</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking - adverse effects</subject><subject>splanchnic vein</subject><subject>Splenic Vein</subject><subject>Thrombosis</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - etiology</subject><issn>1751-2972</issn><issn>1751-2980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkc1P3DAQxa2qqMC2596QJS69BOw4_tje0AIL0gqo-KjUi-U4EzDNJqntLOx_j5eFPXCpL-Oxfu9p_Aah75Qc0HQOqeQ0y8cqtXkqn9DO5uXz5i7zbbQbwiMhXEglvqDtXHDKKGU7yF15qJyNbgG4NjZ2PuCuxqFvTGsfWmfxAlyL44Pv5mUXXMCpM3aIgPtEeDDRRRd-4iMssiUYj4Nr7xvILLQRPIbnHryD1sJXtFWbJsC3tzpCt6cnN5OzbHY5PZ8czTJbSK6yopKFLPLS5gTKuiwoKMWVIaWgxHLCuGUlM0rWBauLamzEuExBmIrXNGe5YmyEfqx9e9_9GyBEPXfBQpM-BN0QNJWCFoJxyhO6_wF97AbfpulWFBHJmKtEHa4p67sQPNS6925u_FJToldb0Kuc9Spz_bqFpNh78x3KOVQb_j32BPA18OQaWP7PT0-Oj9-Ns7XOhQjPG53xf7WQTHL9-2Kq_zB5J35dM33BXgBjaJ-u</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Toqué, Laurence</creator><creator>Hamy, Antoine</creator><creator>Hamel, Jean-Francois</creator><creator>Cesbron, Elodie</creator><creator>Hulo, Pauline</creator><creator>Robert, Solen</creator><creator>Aube, Christophe</creator><creator>Lermite, Emilie</creator><creator>Venara, Aurélien</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience</title><author>Toqué, Laurence ; Hamy, Antoine ; Hamel, Jean-Francois ; Cesbron, Elodie ; Hulo, Pauline ; Robert, Solen ; Aube, Christophe ; Lermite, Emilie ; Venara, Aurélien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4758-4d74742bc20ebfb41e8858a0b610c5035c3b3a87f43f4d9a69b111ad5f1232833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcoholism - complications</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - complications</topic><topic>Incidence</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Mesenteric Veins</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pancreas</topic><topic>pancreatitis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - complications</topic><topic>Portal Vein</topic><topic>Prothrombin Time</topic><topic>Retrospective Studies</topic><topic>risk factor</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Smoking - adverse effects</topic><topic>splanchnic vein</topic><topic>Splenic Vein</topic><topic>Thrombosis</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toqué, Laurence</creatorcontrib><creatorcontrib>Hamy, Antoine</creatorcontrib><creatorcontrib>Hamel, Jean-Francois</creatorcontrib><creatorcontrib>Cesbron, Elodie</creatorcontrib><creatorcontrib>Hulo, Pauline</creatorcontrib><creatorcontrib>Robert, Solen</creatorcontrib><creatorcontrib>Aube, Christophe</creatorcontrib><creatorcontrib>Lermite, Emilie</creatorcontrib><creatorcontrib>Venara, Aurélien</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of digestive diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toqué, Laurence</au><au>Hamy, Antoine</au><au>Hamel, Jean-Francois</au><au>Cesbron, Elodie</au><au>Hulo, Pauline</au><au>Robert, Solen</au><au>Aube, Christophe</au><au>Lermite, Emilie</au><au>Venara, Aurélien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience</atitle><jtitle>Journal of digestive diseases</jtitle><addtitle>Journal of Digestive Diseases</addtitle><date>2015-12</date><risdate>2015</risdate><volume>16</volume><issue>12</issue><spage>734</spage><epage>740</epage><pages>734-740</pages><issn>1751-2972</issn><eissn>1751-2980</eissn><abstract>Objective
Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single‐center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors.
Methods
All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria.
Results
A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively).
In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 109/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT.
Conclusions
Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26513113</pmid><doi>10.1111/1751-2980.12298</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of digestive diseases, 2015-12, Vol.16 (12), p.734-740 |
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| subjects | Adult Aged Alcoholism - complications Female France - epidemiology Humans Hyperglycemia Hyperglycemia - complications Incidence L-Lactate Dehydrogenase - blood Leukocyte Count Male Mesenteric Veins Middle Aged Multivariate Analysis Pancreas pancreatitis Pancreatitis - blood Pancreatitis - complications Portal Vein Prothrombin Time Retrospective Studies risk factor Risk Factors Sex Factors Smoking - adverse effects splanchnic vein Splenic Vein Thrombosis Venous Thrombosis - epidemiology Venous Thrombosis - etiology |
| title | Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience |
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