Botulinum toxin for the treatment of bruxism

• Published in: Cranio 2015-10, Vol.33 (4), p.291-298
• Main Authors: Tinastepe, Neslihan, Küçük, Burcu Bal, Oral, Koray
• Format: Article
• Language: English
• Subjects: Acetylcholine Release Inhibitors - adverse effects; Acetylcholine Release Inhibitors - pharmacology; Acetylcholine Release Inhibitors - therapeutic use; Botulinum Toxins - adverse effects; Botulinum Toxins - pharmacology; Botulinum Toxins - therapeutic use; Bruxism - drug therapy; Dentistry; Humans; Randomized Controlled Trials as Topic
• ISSN: 0886-9634
• DOI: 10.1080/08869634.2015.1097296

Botulinum toxin, the most potent biological toxin, has been shown to be effective for a variety of disorders in several medical conditions, when used both therapeutically and cosmetically. In recent years, there has been a rising trend in the use of this pharmacological agent to control bruxing activity, despite its reported adverse effects. The aim of this review was to provide a brief overview to clarify the underlying essential ideas for the use of botulinum toxin in bruxism based on available scientific papers. An electronic literature search was performed to identify publications related to botulinum toxin and its use for bruxism in PubMed. Hand searching of relevant articles was also made to identify additional studies. Of the eleven identified studies, only two were randomized controlled trials, compared with the effectiveness of botulinum toxins on the reduction in the frequency of bruxism events and myofascial pain after injection. The authors of these studies concluded that botulinum toxin could be used as an effective treatment for reducing nocturnal bruxism and myofascial pain in patients with bruxism. Evidence-based research was limited on this topic. More randomized controlled studies are needed to confirm that botulinum toxin is safe and reliable for routine clinical use in bruxism.