lazarus Is a Novel pbx Gene that Globally Mediates hox Gene Function in Zebrafish

Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and clo...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cell 2000-08, Vol.6 (2), p.255-267
Main Authors: Pöpperl, Heike, Rikhof, Holly, Cheng, Heather, Haffter, Pascal, Kimmel, Charles B., Moens, Cecilia B.
Format: Article
Language:English
Subjects:
Animals
Body Patterning - genetics
Danio rerio
DNA-Binding Proteins - genetics
Embryo, Nonmammalian - physiology
Exd protein
Gene Expression Regulation
Genes, Homeobox
Genes, Regulator
hox gene
hox protein
lazurus gene
Mutagenesis
pbx gene
Pbx protein
Polymerase Chain Reaction
Pre-B-Cell Leukemia Transcription Factor 1
Proto-Oncogene Proteins - genetics
Rhombencephalon - embryology
Zebrafish - embryology
Zebrafish - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(00)00027-7