Serum paraoxonase-1 activity and risk of incident cardiovascular disease: The PREVEND study and meta-analysis of prospective population studies

Abstract Background Paraoxonase-1 (PON-1) has been suggested to be associated with cardiovascular disease (CVD) risk, however, aspects of the association, such as shape and independence from conventional risk factors are still uncertain. We aimed to assess the association of PON-1 with CVD risk and...

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Bibliographic Details
Published in:Atherosclerosis 2016-02, Vol.245, p.143-154
Main Authors: Kunutsor, Setor K, Bakker, Stephan J.L, James, Richard W, Dullaart, Robin P.F
Format: Article
Language:English
Subjects:
Aryldialkylphosphatase - blood
Biomarkers - blood
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - enzymology
Cardiovascular Diseases - epidemiology
Global Health
Humans
Meta-analysis
Morbidity - trends
Paraoxonase-1
Population Surveillance
Prospective Studies
Risk Assessment - methods
Risk factor
Risk Factors
Risk prediction
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Summary:Abstract Background Paraoxonase-1 (PON-1) has been suggested to be associated with cardiovascular disease (CVD) risk, however, aspects of the association, such as shape and independence from conventional risk factors are still uncertain. We aimed to assess the association of PON-1 with CVD risk and determine its potential utility for CVD risk prediction. Methods PON-1 was measured as its arylesterase activity at baseline in the PREVEND prospective study of 6902 participants. Results During a mean follow-up of 9.3 years, 730 CVD events were recorded. Serum PON-1 was weakly correlated with several cardiovascular risk markers including high-density lipoprotein cholesterol (HDL-C) (r = 0.18; P  
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.12.021