The effects of linear and cyclic analogs of Locmi-DH, Dippu-DH46 and Dippu-DH31 on appetitive behavior in Locusta migratoria

• Published in: Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-03, Vol.34 (1), p.258-261
• Main Authors: Kaskani, Charoula, Poulos, Constantine P., Goldsworthy, Graham J.
• Format: Article
• Language: English
• Subjects: Analogs; Dipping; Diuretics; Dosage; Fragments; Locusta migratoria; Locusts; Meals; nymphs; Peptides
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/j.peptides.2011.04.009

► We investigated aspects of appetitive behavior of analogs of the diuretic peptides Locmi-DH, Dippu-DH46 and Dippu-DH31. ► The linear fragments and their cyclic analogs of Dippu-DH46 display no significant effects on the latency to feed. ► The linear fragments of Dippu-DH31 and their cyclic analogs, and analogs of Locmi-DH modulate appetitive behavior: they are anorexigenic in reducing the duration of the first meal, and increasing the latency to feed. The effects of analogs of the diuretic peptides Locmi-DH, Dippu-DH46 and Dippu-DH31 on two aspects of appetitive behavior are investigated in previously food-deprived nymphs of Locusta migratoria. The analogs tested are the C-terminal 15-mer and nonapeptides and their corresponding cyclic analogs. At a nominal dose of 1pmol injected per nymph, the linear fragments and their cyclic analogs of Dippu-DH46 display no significant effects on the latency to feed or on the length of the first meal in nymphs. However, at the same dose, the linear fragments of Dippu-DH31 and their cyclic analogs, and analogs of Locmi-DH modulate appetitive behavior: they are anorexigenic in reducing the duration of the first meal, and generally increasing the latency to feed. The cyclic analogs of Dippu-DH31 are at least as effective as their linear counterparts in influencing these aspects of appetitive behavior in locust nymphs.