Graphite Nanoplatelets and Caenorhabditis elegans: Insights from an in Vivo Model

We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also dev...

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Bibliographic Details
Published in:Nano letters 2012-06, Vol.12 (6), p.2740-2744
Main Authors: Zanni, Elena, De Bellis, Giovanni, Bracciale, Maria P, Broggi, Alessandra, Santarelli, Maria L, Sarto, Maria S, Palleschi, Claudio, Uccelletti, Daniela
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biomedical materials
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - physiology
Cross-disciplinary physics: materials science
rheology
Dose-Response Relationship, Drug
Exact sciences and technology
Fullerenes and related materials
diamonds, graphite
Graphite
Graphite - toxicity
In vivo testing
In vivo tests
Materials science
Nanocrystalline materials
Nanoparticles - toxicity
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Nematodes
Physics
Specific materials
Surgical implants
Survival Rate
Toxicity
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Summary:We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also developed to analyze the GNPs spatial distribution inside the nematodes. Conflicting reports on the in vitro antimicrobial properties of graphene-based nanomaterials prompted us to challenge the host–pathogen system C. elegans–Pseudomonas aeruginosa to assess these findings through an in vivo model.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl204388p