Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation

Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-...

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Bibliographic Details
Published in:ACS nano 2015-08, Vol.9 (8), p.7874-7885
Main Authors: Zhu, Aijun, Miao, Ke, Deng, Yibin, Ke, Hengte, He, Hui, Yang, Tao, Guo, Miao, Li, Yanli, Guo, Zhengqing, Wang, Yangyun, Yang, Xiangliang, Zhao, Youliang, Chen, Huabing
Format: Article
Language:English
Subjects:
Ablation
Acrylic Resins - chemistry
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug Carriers
Drug Liberation
Drugs
Female
Fluorescence
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Hydrogen-Ion Concentration
Hyperthermia, Induced - methods
Imaging
Indocyanine Green - chemistry
Indocyanine Green - pharmacology
Mammary Neoplasms, Animal - diagnosis
Mammary Neoplasms, Animal - pathology
Mammary Neoplasms, Animal - therapy
Mice
Mice, Nude
Nanostructure
Nanostructures - chemistry
Nanostructures - therapeutic use
Nanostructures - ultrastructure
Optical Imaging - methods
Oxidation-Reduction
Particle Size
Photochemical Processes
Polyesters - chemistry
Polyethylene Glycols - chemistry
Singlet Oxygen - metabolism
Theranostic Nanomedicine - methods
Therapy
Vesicles
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Summary:Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution. These multiple theranostic features result in ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. The dually stimuli-responsive vesicles represent a versatile theranostic approach for enhanced cancer imaging and therapy.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.5b02843