Amplified Photoacoustic Performance and Enhanced Photothermal Stability of Reduced Graphene Oxide Coated Gold Nanorods for Sensitive Photoacoustic Imaging

We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat tra...

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Bibliographic Details
Published in:ACS nano 2015-03, Vol.9 (3), p.2711-2719
Main Authors: Moon, Hyungwon, Kumar, Dinesh, Kim, Haemin, Sim, Changbeom, Chang, Jin-Ho, Kim, Jung-Mu, Kim, Hyuncheol, Lim, Dong-Kwon
Format: Article
Language:English
Subjects:
Amplification
Amplitudes
Animals
Coating
Drug Stability
Female
Finite Element Analysis
Gold
Gold - chemistry
Graphene
Graphite - chemistry
Imaging
Infrared Rays
Mice
Mice, Inbred BALB C
Models, Molecular
Molecular Conformation
Nanorods
Nanotubes - chemistry
Optical Phenomena
Oxidation-Reduction
Oxides
Oxides - chemistry
Photoacoustic Techniques - methods
Temperature
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Summary:We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4–11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn506516p