Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortol...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (84), p.15378-15381
Main Authors: Wen, Qiaodong, Lu, Ping, Wang, Yanguang
Format: Article
Language:English
Subjects:
Acetonitriles - chemistry
Acetophenone
Acetophenones - chemistry
Aminopyridines - chemistry
Cascade chemical reactions
Catalysis
Copper - chemistry
Cyanides
Imidazoles - chemical synthesis
Imidazoles - chemistry
Molecular Structure
Pyridines - chemical synthesis
Pyridines - chemistry
Synthesis
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Summary:A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05821j