Synthesis, spectroscopic, thermal and biological aspects of drug-based copper(II) complexes

• Published in: Applied organometallic chemistry 2011-06, Vol.25 (6), p.454-463
• Main Authors: Patel, Paresh N., Patel, Darshana J., Patel, Hasmukh S.
• Format: Article
• Language: English
• Subjects: Activation energy; antibacterial activity; Bacteria; Biological; Cu(II) complexes; Entropy; Freeman-Carroll method; Ligands; Pseudomonas aeruginosa; Reflectance; Serratia marcescens; spectroscopic
• ISSN: 0268-2605; 1099-0739; 1099-0739
• DOI: 10.1002/aoc.1786

A series of novel complexes of the type Cu(II)(Ln)2(H2O)2]•xH2O [where Ln = L1–4, these ligands being described as: L1, 2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 1; L2, 2‐({4‐[6,7‐dihydrothieno[3,2‐c] pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)‐5‐(methoxy)phenol, x = 2; L3, 5‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 2; and L4, 5‐bromo‐4‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino} methyl)phenol, x = 1] was investigated. They were characterized by elemental analysis, IR, 1H‐NMR, 13C‐NMR and electronic spectra, magnetic measurements and thermal studies. The FAB‐mass spectrum of [Cu(II)(L1)2(H2O)2]•H2O was determined. A magnetic moment and reflectance spectral study revealed that an octahedral geometry could be assigned to all the prepared complexes. Ligands (Ln) and their metal complexes were screened for their in vitro antibacterial activity against Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Serratia marcescens bacterial strains. Kinetic parameters such as order of reaction (n), the energy of activation (Ea), the pre‐exponential factor (A), the activation entropy (ΔS≠), the activation enthalpy (ΔH≠) and the free energy of activation (ΔG≠) are reported. Copyright © 2011 John Wiley & Sons, Ltd. A series of novel complexes of the type [Cu(II)(Ln)2(H2O)2]•xH2O have been investigated, and characterized by elemental, spectra, magnetic measurements and thermal studies. A magnetic moment and reflectance spectral study reveals that an octahedral geometry has been assigned to all the prepared complexes. All these compounds were screened for their in‐vitro antibacterial activity. Also their kinetic parameters have been reported.