Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization

Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, pla...

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Published in:Molecular and cellular endocrinology 2013-12, Vol.381 (1-2), p.272-279
Main Authors: Zhang, Xiu-Hong, Liang, Xuan, Wang, Tong-Song, Liang, Xiao-Huan, Zuo, Ru-Juan, Deng, Wen-Bo, Zhang, Zhi-Rong, Qin, Fu-Niu, Zhao, Zhen-Ao, Yang, Zeng-Ming
Format: Article
Language:English
Subjects:
Animals
blastocyst
Cells, Cultured
Crosstalk
Cyclooxygenase 2 - genetics
Cyclooxygenase 2 - metabolism
Decidua
Decidua - metabolism
Embryo Implantation
Embryos
Female
Genes
Growth factors
HB-EGF
Heparin-binding EGF-like Growth Factor
Implantation
Inhibitors
Intercellular Signaling Peptides and Proteins - physiology
Male
MAP Kinase Signaling System
Mice
Phosphorylation
Pregnancy
Protein Processing, Post-Translational
Receptor, Epidermal Growth Factor - metabolism
small interfering RNA
Snail
Snail Family Transcription Factors
Snails
STAT3 Transcription Factor - metabolism
stromal cells
Transcription Factors - genetics
Transcription Factors - metabolism
Transcriptional Activation
Uterus
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Summary:Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role during epithelial–mesenchymal transition. Our previous study showed that Snail is highly expressed at implantation site in mouse uterus. This study was to examine how Snail is related with other implantation-related genes in mice. Uterine stromal cells were isolated from mouse uteri on day 4 of pregnancy and treated with HB-EGF. Snail was induced significantly by HB-EGF. By using specific inhibitors and siRNA, we demonstrated that HB-EGF induction on Snail expression is dependent on the EGFR-ERK-Stat3 pathway. Cox-2 was regulated by Snail. The current findings demonstrate that Snail can relate with HB-EGF, Stat3 and Cox-2 and may play a role during mouse embryo implantation and decidualization.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2013.08.011