Hopanoids are formed during transition from substrate to aerial hyphae in Streptomyces coelicolor A3(2)

Streptomyces coelicolor A3(2) contains a cluster of putative isoprenoid and hopanoid biosynthetic genes. The strain does not produce the pentacyclic hopanoids in liquid culture but produces them on solid medium when sporulating. Mutants defective in the formation of aerial mycelium and spores ( bld)...

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Bibliographic Details
Published in:FEMS microbiology letters 2000-08, Vol.189 (1), p.93-95
Main Authors: Poralla, Karl, Muth, Günther, Härtner, Thomas
Format: Article
Language:English
Subjects:
Differentiation
Hopanoid
hopanoids
Isoprenoid
Streptomyces coelicolor
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Description
Summary:Streptomyces coelicolor A3(2) contains a cluster of putative isoprenoid and hopanoid biosynthetic genes. The strain does not produce the pentacyclic hopanoids in liquid culture but produces them on solid medium when sporulating. Mutants defective in the formation of aerial mycelium and spores ( bld), with the exception of bldB, do not synthesize hopanoids, whereas mutants, which form aerial mycelium but no spores ( whi), do. The membrane condensing hopanoids possibly may alleviate stress in aerial mycelium by diminishing water permeability across the membrane.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(00)00259-7