Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration

Purpose To compare the incidence of contrast-induced nephropathy (CIN) for intravenous vs. intra-arterial administration of iodixanol, compared to non-administration. Methods We retrospectively identified 650 patients who had intravenous iodixanol-enhanced CT, 695 with intra-arterial iodixanol cardi...

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Bibliographic Details
Published in:Abdominal imaging 2016-01, Vol.41 (1), p.91-99
Main Authors: Tong, Gregory E., Kumar, Sant, Chong, Karen C., Shah, Nikita, Wong, Margaret J., Zimmet, Jeffrey M., Wang, Zhen Jane, Yee, Judy, Fu, Yanjun, Yeh, Benjamin M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cardiac Catheterization
Contrast Media - administration & dosage
Contrast Media - adverse effects
Creatinine - blood
Female
Gastroenterology
Glomerular Filtration Rate
Hepatology
Humans
Imaging
Injections, Intra-Arterial - adverse effects
Injections, Intravenous - adverse effects
Kidney Diseases - chemically induced
Male
Medicine
Medicine & Public Health
Middle Aged
Radiology
Retrospective Studies
Risk
Tomography, X-Ray Computed
Triiodobenzoic Acids - administration & dosage
Triiodobenzoic Acids - adverse effects
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Summary:Purpose To compare the incidence of contrast-induced nephropathy (CIN) for intravenous vs. intra-arterial administration of iodixanol, compared to non-administration. Methods We retrospectively identified 650 patients who had intravenous iodixanol-enhanced CT, 695 with intra-arterial iodixanol cardiac catheterization, 651 with unenhanced CT, and those who also had baseline and follow-up serum creatinine within 5 days of the exam. From the medical records, we recorded the gender, age, baseline and follow-up serum creatinine/eGFR; underlying renal injury risk factors; indication for imaging; contrast material administration volume, concentration, and route of administration; and use of pre-imaging prophylactic measures for CIN. Univariate and multivariate models were used to determine predictors of CIN. Results Baseline eGFR was lower for patients undergoing unenhanced CT than intravenous or intra-arterial patients (68 vs. 74.6 and 72.2, respectively, p  
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-015-0611-9