Perioperative treatment and radical cystectomy for bladder cancer – a population based trend analysis of 10,338 patients in the Netherlands

Abstract Background In Europe, population-based data concerning perioperative treatment (PT) and radical cystectomy (RC) are lacking. We assessed temporal trends in PT (neoadjuvant chemotherapy [NAC], neoadjuvant radiotherapy [NAR], adjuvant chemotherapy [AC], adjuvant radiotherapy [AR]) and RC in t...

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Bibliographic Details
Published in:European journal of cancer (1990) 2016-02, Vol.54, p.18-26
Main Authors: Hermans, Tom J.N, Fransen van de Putte, Elisabeth E, Horenblas, Simon, Lemmens, Valery, Aben, Katja, van der Heijden, Michiel S, Beerepoot, Laurens V, Verhoeven, Rob H, van Rhijn, Bas W.G
Format: Article
Language:English
Subjects:
Adjuvant
Adolescent
Adult
Age Factors
Aged
Bladder
Cancer
Chemotherapy
Chemotherapy, Adjuvant
Child
Child, Preschool
Cystectomy
Cystectomy - trends
Female
Hematology, Oncology and Palliative Medicine
Hospitals, Teaching
Humans
Infant
Infant, Newborn
Logistic Models
Male
Middle Aged
Multivariate Analysis
Neoadjuvant
Neoadjuvant Therapy - trends
Neoplasm Grading
Neoplasm Staging
Netherlands - epidemiology
Practice Patterns, Physicians' - trends
Radiotherapy
Radiotherapy, Adjuvant
Registries
Retrospective Studies
Time Factors
Treatment Outcome
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
Young Adult
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Summary:Abstract Background In Europe, population-based data concerning perioperative treatment (PT) and radical cystectomy (RC) are lacking. We assessed temporal trends in PT (neoadjuvant chemotherapy [NAC], neoadjuvant radiotherapy [NAR], adjuvant chemotherapy [AC], adjuvant radiotherapy [AR]) and RC in the Netherlands and identified patients' and hospital characteristics associated with PT. Methods This nationwide, retrospective, population-based study included cTa/is, T1-4, N0-3, M0-1 bladder cancer patients from the Netherlands Cancer Registry who underwent RC with curative intent between 1995 and 2013. PT-administration over time was compared with chi-square tests. Multivariable logistic regression analyses were performed to identify characteristics associated with PT usage. The sub-groups cT2-4N0M0 and cT2-4, N0 or NX, M0 or MX were separately analysed. Results In total, 10,338 patients met inclusion criteria. Eighty-six percent did not receive PT, 7.0% received NAC (or induction chemotherapy [IC]), 3.2% NAR, 1.8% AC, and 2.1% AR. NAC usage increased from 0.6% in 1995 to 21% in 2013 (p 
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2015.11.006