Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice

Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2016/02/01, Vol.39(2), pp.272-277
Main Authors: Matsuoka, Takeshi, Kurohane, Kohta, Suzuki, Wakana, Ogawa, Erina, Kobayashi, Kamiyu, Imai, Yasuyuki
Format: Article
Language:English
Subjects:
adjuvant
Animals
contact hypersensitivity
cytokine production
Cytokines - genetics
Cytokines - metabolism
dendritic cell trafficking
Dermatitis, Contact
dibutyl fumarate
dibutyl maleate
Drug Hypersensitivity
Fluorescein-5-isothiocyanate - toxicity
Fumarates - toxicity
Gene Expression Regulation - drug effects
Gene Expression Regulation - immunology
Lymph Nodes - metabolism
Maleates - toxicity
Mice
Mice, Inbred BALB C
Molecular Structure
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Summary:Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a butyl alcohol ester of di-carboxylic acid that represents a part of the DBP structure, while di-n-butyl fumarate (DBF) is a trans isomer of DBM. We examined whether DBM or DBF exhibits an adjuvant effect like DBP does. When BALB/c mice were epicutaneously sensitized with FITC in the presence of DBM or DBF, the FITC-specific CHS response was enhanced, as we have observed for DBP. As to underlying mechanisms, DBM and DBF facilitated the trafficking of FITC-presenting CD11c+ dendritic cells (DCs) from skin to draining lymph nodes and increased the cytokine production by draining lymph nodes. In conclusion, DBM and DBF may have an effect that aggravates contact dermatitis through a skin sensitization process.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b15-00683