Non-invasive prediction of portal pressures using CT and MRI in chronic liver disease

• Published in: Abdominal imaging 2016, Vol.41 (1), p.42-49
• Main Authors: Kihira, Shingo, Kagen, Alexander C., Vasudevan, Prasanna, Jajamovich, Guido H., Schiano, Thomas D., Andrle, Anne-Fleur, Babb, James S., Fischman, Aaron, Taouli, Bachir
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biopsy; Chronic Disease; Contrast Media; Female; Gastroenterology; Hepatology; Humans; Hypertension, Portal - diagnosis; Hypertension, Portal - diagnostic imaging; Imaging; Liver Diseases - complications; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Predictive Value of Tests; Radiology; Retrospective Studies; Tomography, X-Ray Computed
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-015-0614-6

Purpose To assess the diagnostic value of a fast scoring system based on non-invasive cross-sectional imaging to predict portal hypertension (PH) in patients with liver disease. Methods In this retrospective study, we included patients who underwent contrast-enhanced CT or MRI within 3 months of hepatic venous pressure gradient (HVPG) measurements. Two independent observers provided an imaging-based scoring system (max of 9): number of variceal sites, volume of ascites, and spleen size. ROC analysis was performed to predict the presence of PH (HVPG ≥ 5 mmHg) and clinically significant PH (HVPG ≥ 10 mmHg). Results Our cohort consists of 143 patients with mean HVPG of 13.1 ± 2.0 mmHg. Mean PH scores from the two observers were 3.9 ± 2.7 and 3.2 ± 2.5. There was a significant correlation between PH score and HVPG ( r  = 0.58, p