New insights into the role of stromal cell-derived factor 1 (SDF-1/CXCL12) in the pathophysiology of multiple sclerosis

Abstract The etiology of several autoimmune diseases, including multiple sclerosis (MS) is still not clarified. MS is defined as an autoimmune disease with clinical features of a chronic, inflammatory, and demyelinating autoimmune disorder, which affects the central nervous system. Phases of remissi...

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Bibliographic Details
Published in:Journal of neuroimmunology 2016-01, Vol.290, p.70-75
Main Authors: Khorramdelazad, Hossein, Bagheri, Vahid, Hassanshahi, Gholamhossein, Zeinali, Masoud, Vakilian, Alireza
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Chemokine CXCL12 - physiology
CXC chemokine
CXCL12
Cytokines - physiology
Humans
Lymphocytes - physiology
Monocytes - physiology
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Neurology
SDF-1
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Summary:Abstract The etiology of several autoimmune diseases, including multiple sclerosis (MS) is still not clarified. MS is defined as an autoimmune disease with clinical features of a chronic, inflammatory, and demyelinating autoimmune disorder, which affects the central nervous system. Phases of remission and relapse are the major course of the disease, which could be exacerbated in terms of both severity and duration. As a subfamily of the cytokines, chemokines act as chemoattractants for a wide variety of cells, including immune cells. CXCL12, which is an important member of the CXC subfamily, has been widely explored in the hematopoietic system. In the peripheral immune system, CXCL12/CXCR4 performs pleiotropic functions. CXCL12 is a highly effective chemoattractant for lymphocytes and monocytes but not neutrophils. CXCL12 is present in the cerebrospinal fluid (CSF) of patients with MS and other inflammatory neurological disorders. The aim of this study is to summarize recent findings regarding the relationship between CXCL12 and MS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2015.11.021