Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis

Highlights • Sevoflurane-induced neuronal apoptosis could be attenuated by mGluR7 activator LAP4 or AMN082. • β-Arr2-dependent Phospho-ERK1/2 reduces sevoflurane neurotoxicity by inhibiting Phospho-Bad. • β-Arr1 modulates mGluR7 signaling by interacting with CBP and p300 in sevoflurane neurotoxicity...

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Published in:Neuroscience 2016-01, Vol.313, p.199-212
Main Authors: Wang, W.-Y, Wu, X.-M, Jia, L.-J, Zhang, H.-H, Cai, F, Mao, H, Xu, W.-C, Chen, L, Zhang, J, Hu, S.-F
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Arrestins - genetics
Arrestins - metabolism
Benzhydryl Compounds - pharmacology
beta-Arrestin 1
beta-Arrestin 2
beta-Arrestins
Brain - drug effects
Brain - growth & development
Brain - pathology
Brain - physiopathology
Cells, Cultured
CREB-Binding Protein
developing brain
Disease Models, Animal
Emotions - drug effects
Emotions - physiology
ERK1/2
Excitatory Amino Acid Agents - pharmacology
Learning Disorders - chemically induced
Learning Disorders - drug therapy
Learning Disorders - pathology
Learning Disorders - physiopathology
Memory Disorders - chemically induced
Memory Disorders - drug therapy
Memory Disorders - pathology
Memory Disorders - physiopathology
Methyl Ethers - toxicity
mGluR7
Neurology
Neurons - drug effects
Neurons - pathology
Neurons - physiology
Neurotoxicity Syndromes - pathology
Neurotoxicity Syndromes - physiopathology
Rats, Sprague-Dawley
Receptors, Metabotropic Glutamate - agonists
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, Metabotropic Glutamate - metabolism
RNA, Small Interfering - administration & dosage
sevoflurane
Signal Transduction - drug effects
Signal Transduction - physiology
β-arrestins
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Summary:Highlights • Sevoflurane-induced neuronal apoptosis could be attenuated by mGluR7 activator LAP4 or AMN082. • β-Arr2-dependent Phospho-ERK1/2 reduces sevoflurane neurotoxicity by inhibiting Phospho-Bad. • β-Arr1 modulates mGluR7 signaling by interacting with CBP and p300 in sevoflurane neurotoxicity. • LAP4 or AMN082 improves postnatal sevoflurane-induced emotional and spatial cognitive deficits.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.038